Comment on “Urea-Mediated Protein Denaturation: A Consensus View”
نویسندگان
چکیده
منابع مشابه
Comment on "urea-mediated protein denaturation: a consensus view".
Comment on “Urea-Mediated Protein Denaturation: A Consensus View” Ruhong Zhou,* Jingyuan Li, Lan Hua, Zaixing Yang, and B. J. Berne* IBM Thomas J. Watson Research Center, Yorktown Heights, New York 10598, United States Department of Chemistry, Columbia University, New York, New York 10027, United States Department of Pharmaceutical Chemistry, University of California at San Francisco, San Franc...
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Because of its protein-denaturing ability, urea has played a pivotal role in the experimental and conceptual understanding of protein folding and unfolding. The measure of urea's ability to force a protein to unfold is given by the m value, an experimental quantity giving the free energy change for unfolding per molar urea. With the aid of Tanford's transfer model [Tanford C (1964) J Am Chem So...
متن کاملInteraction of urea with amino acids: implications for urea-induced protein denaturation.
The molecular mechanism of urea-induced protein denaturation is not yet fully understood. Mainly two opposing mechanisms are controversially discussed, according to which either hydrophobic, or polar interactions are the dominant driving force. To resolve this question, we have investigated the interactions between urea and all 20 amino acids by comprehensive molecular dynamics simulations of 2...
متن کاملComment on"A simple model for DNA denaturation"
where ri(s) is the d-dimensional position coordinate of a monomer point at a contour length s of chain i, each of length N , V is the base pairing interaction at the same contour length (“directed polymer” interaction), Hev is the mutual excluded volume (ev) interaction represented by the u0 > 0 term with δΛ(r) as the usual delta function with an ultraviolet cut-off Λ in the reciprocal space. T...
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ژورنال
عنوان ژورنال: The Journal of Physical Chemistry B
سال: 2011
ISSN: 1520-6106,1520-5207
DOI: 10.1021/jp105160a